Stories from Bengal Owners about Ketamine Anaesthetic!!

1. He had a BAD reaction to the Ketamine shot. When he came out of the anesthesia he started clawing at his face. I had to restrain him from really hurting himself. The vet gave him valium IV and it calmed him. In almost all cases it is very important to tranquilize the cats before giving Ketamine. Ketamine causes hallucinations. If they are pre-tranquilized they do still paw at their mouths but it is not so frantic.

Animals that are agitated when going under are agitated coming out. I have had kittens spayed and neutered early for 4 years and had not seen the violent reaction as you described until last night when I was helping my vet send cats home after surgery. One girl did have a very stressed wake up period. Because she was so nervous at the vet's we were guessing the adrenaline caused her to burn off the tranquilizer faster before the ketamine. Ketamine is better if not used alone.

-------

2. At behavior seminars, it has been pointed out that 20% of all cats will spray... male and female, whole and altered. The difference lies in some do it to be attractive to the opposite sex, some do it to make a territory "their own" and some do it for a variety of reasons. The main reason cats end up in shelters is the marking problem... so as breeders, we need to consider long and hard what it means when one of our cats ends up spraying... and help people to minimalize the possibility.

Altered cats often spray or squat, the idea is the same. Cat spray is simply urine... the idea of spraying is to make the highest mark possible showing the world "I am the biggest and toughest around!" Early spay and neuter is thought to help, but has not been proven definitively to my knowledge, though it is a logical step and is well worth the effort.  A neutered male in a home with yowling females, might be tempted to try masculine behavior... after all the adrenal glands continue to produce hormones..... so....

------

3. My folder had always stated "isoflorane only" for any of my cats undergoing surgery for whatever reason, not to allow the use of Ketamine.

Re: Ketamine: After the near death experience I had from Ketamine the doctors told me it was like a "BAD LSD TRIP." Why they used it on me was because they said having to lie on the stomach in surgery can affect breathing and it was believed Ketamine would have eased that problem. Instead it left me in a deep coma for seven days in hell. And it cause serious permanent damage to my brain waves which has left me an insomniac. And for the three months after surgery, I convulsed.

I cannot believe that the public has been denied this info for so many years. But then how many other drugs are used that are known to kill and are still on the public market and prescribed by doctors regularly??

A friend was given chemo for lymphoma, which is a known drug for destroying muscle, heart, and connective tissue. It blinded her. And it is still being used. How many of our animals have suffered from treatments that have hurt them? Sometimes the medical treatments are as challenging or even worse than the illnesses.

---------

4. XXXX..... many thanks for writing the list and informing them of the abreaction your little one suffered from the Ketamine. I had a similar experience. I took one of our male Bengal kittens in to be neutered last year they gave him pre-anesthesia Ketamine before the surgery then gave him Gas on the table during the procedure. well when we picked him up at 4 pm, (surgery was at 9 am and we had to have him in by 7 am) he was so crocked he was rolling like a ball he was so out of it. They told us to keep him in a safe quite place. All the way home in the car he was thrashing and rolling in the carrier he was hitting his head so bad I was afraid of brain damage. So I pulled over and took him out and tried to drive and restrain him at the same time. Not an easy task. Anyway, got him home and put him in a small room, I heard nothing but bang, bang, bang as he rammed into every object in the room making mad dashes or tries to stand up and run. he actually bloodied his nose and forehead from hitting objects.

I called my vet who said it will wear off, he needs fluids to flush it thru his system. I said there is no way this cat is going to even know that there is water or food in front of him because he can't even control one movement. It was horrible to watch. My kids were crying and I was upset. Like you, I have NEVER seen this reaction to anesthesia. I was a good 3 to 4 days before he was back to his good ole self.

Dear XXXXX.... I nearly died from Ketamine when it was given to me as an anesthesia. 7 days in profound coma. Seriously and dangerously hurt by this drug. Did not know it was used on animals. Lucky kitten he had you for a protector. I wish you had been with me when they nearly took my life with Ketamine. You are a very good kitty mom. 

--------

5. The Anesthesia used was Ketamine, and apparently young kittens are very sensitive to the dosage. I think that the Isofluorane that most vets currently use is much safer as they don't get a fixed injection, but rather it's a gas they breathe. Someone should do some research and write an article for the Bulletin. Heather would probably really appreciate it.

My vet has used Ketamine on my early spay/neuter kittens for 4 years. It is very important to tranquilize them before the Ketamine and I know other drugs are used with it.

The problems described on the list have not happened to my or the kittens she does. She is a spay/neuter clinic and does between 8 to 12 a day. When they come out they do paw at their mouths a little bit--none of the frantic and self destructive ways that have been described on the list.

Maybe some of these vets need to get out their med. books and reread their anesthesia protocols?

--------

6. According to my vet, and I printed and showed her some of that thread (names
withheld, of course), she felt that the kittens/cats had been overdosed. She also said that isofluorane does not kill pain; that other elements are used in conjunction with Ketamine; and that she flushes out the anesthesia from the system via IV after surgery.

She is really "anal" about drugs, including antibiotics, and is really dedicated to the animals.  She's very conservative, and says that it's *very* easy to overdose an animal with Ketamine.

---------

7. Hi,  I am coming out of lurk mode to set down a few facts about Ketamine.  For those who have had problems either with their kitties or personally, I am truly sorry.  But as all of you know, there are no perfect drugs/medications/anesthetics out there.  Nothing is totally innocuous.

All, no matter whether you inhale them, ingest them, or get them parentally, have some side effects and/or possible complications. Everything has the potential to cause problems.  I have seen a patient almost bleed to death from a "natural" drug.  And everything has side effects, whether you actually see them or not.

Ketamine is a very good drug under certain conditions.  And in the 30+ years it has been around, it has been administered several hundred thousand times with few catastrophes.  We used to give it a lot for some things, such as patients who required frequent anesthetics for burn debridements and grafting where giving any other kind of anesthetic was not only almost impossible or not advisable.  Yes, they did complain of "bad trips" occasionally, and we gave other things in combination to try to minimize those.  Ketamine is one of the very few anesthetics that does not depress BP, pulse and respirations , so is very good in shock conditions, and they do not lose all of the vital reflexes such as swallowing, etc.  With some of the newer anesthetics being developed, Ketamine is not used as frequently.  But again, even the newer ones can on occasion, cause catastrophic results.

In addition to the known side effects of all drugs, there is always the possibility of an allergic reaction.  As has been noted, these do not always manifest themselves on the first administration.  And one has to be prepared to counter that almost immediately.  Fortunately, there is nearly always something that can be done if it is recognized in time.

I am sure the vet who got the bad reaction to Ketamine was as shocked as anybody else.  Many thousands of animals have received it safely with no reaction whatsoever.  All of my cats, including the Bengals, have received it at one time or another, and other than "cash register" eyes and confusion for a bit, have suffered no sequelae.  So what I am trying to say, is don't just totally discount this drug just because of one or two horror stories.  Always talk to the vet or whoever administers the anesthetic about your fears and concerns.

Any further questions, concerns, what-have-you about anesthetics, I will be more than happy to answer. Connie (going back to lurk mode)

---------

8. I am sure that most of you can do a search on the net about Ketamine.  Here is some of the sites that I found.  Also, Ketamine is used as a intra-muscular, pre-operative relaxant.

http://www.fabcats.org/is5.html
http://www.canjneurolsci.org/21augtoc/large.htm
http://www.vetinfo.com/catindex.html 
 
With this listing, I found a multitude of listings, A - Z, Ketamine was listed safe if mixed with Isoflourine, not recommend with conjunction with Halothan gas though.

Peruse these sights, but I think the best site, so far, the last one.

--------

9.  Since this has come up, I am going to share some experiences with anesthetics and cats. Mr. Claws, my older neutered male Bengal seemed to stumble around confused for hours after having gone under anesthetic. it always made me feel uncomfortable, because it reminded me of how I've seen animals act after an epileptic seizure. then Jitterbug had one Bengal kitten with a dip in her back. I decided on the advice of several people to have her x-rayed to see if there was anything wrong. she had to go under anesthetic for this, so she would lie perfectly still. when I went to pick her up in the afternoon after having to leave her half the day, (the usual occurrence with general anesthetic) I could hear a cat screaming non-stop from the parking lot. it was her. they said she had been doing that since she woke up. I never heard anything like that from her before or after. they tried everything to comfort her, but she didn't quiet down until she was in my arms. (boy were they glad to see me!) even then, if I tried to put her in the carrier, or stopped petting or talking to her, she started screaming again. then something else odd happened. I was standing near a computer printer when it suddenly started. she almost jumped out of my arms trying to get away. I had to hang on to her for dear life. it was similar to the printer I have at home, and I always had to pull her away from mine when it started, because she tried to chase the paper through, and I was afraid she would get a paw or her tail caught in the rollers. what does that stuff do to these animals to make them act so strange and make them suffer so?

I have a new vet, now. she uses isoflourane gas exclusively. the first experience I had with this stuff was when I took Jitterbug and Mr. Claws in to be blood typed. they had to shave their necks and take a large amount of blood from the juggler veins. my new vet wanted to put them out for this. I was reluctant, but then I thought of them going through all that and the dangers of sticking a big needle in the neck of a squirming, screaming Bengal and decided it would probably be best. my cats were brought back in minutes, not hours or half a day. they were fresh, alert and bright-eyed as though they had just awoke from a cat nap.

I am very pleased with isoflourane. it is administered by putting a little mask over the cat's nose instead of an injection and seems to do its job effectively, and seems to allow them to recover very quickly and easily. this is particularly valuable for animals that have serious health problems, such as heart or kidney disease, that would make the normal anesthetic life threatening. talk to your vet. do some research. it's worth looking into.

Since I wrote that, I found some info on ketamine. this is the website.

http://units.ox.ac.uk/departments/anaesthetics/wfsa/html/u04/u04_010.htm

Here's another quote from another site.

Ketamine is a racemic mixture containing equal parts of S-(+)-ketamine and R-(-)-ketamine. Their potency relation is approximately 4:1. In early human studies S-(+)- ketamine was presumed to produce the desired anaesthetic effects and R-(-)-ketamine the undesired psychic emergence reactions. Therefore, ketamine was compared in a number of randomized studies in volunteers and patients with racemic ketamine. This review addresses the impact of S-(+)-ketamine on recovery from anaesthesia, incidence and content of vivid dreams, and other side effects. The dose relation applied in the studies was 1:2. With only one exception, the recovery phase was clearly shorter after S-(+)-ketamine compared to racemic ketamine irrespective of its application as a single bolus, a bolus followed by continuous infusion, or an intramuscular injection. However, the incidence of psychic emergence reactions was lower after S-(+)-ketamine in only a single study. In conclusion, S-(+)-ketamine should be always combined with a hypnotic or sedative drug in clinical anaesthesia.

So, it appears that a number of vets do not administer it correctly--either do not bother to combine it with the medication that is supposed to counteract the "psychotic inducing" effects or don't use the correct proportions. I also read an article that compared this drug to angel dust. if anyone doesn't remember that stuff, druggies used to sprinkle it on pot or parsley or whatever and smoke it back in the seventies. then they would go around doing weird stuff, like babbling a bunch of nonsense, becoming out of control and violent, or doing swan dives out of 20-story windows. now do you remember?

Here's something else I found. You'll like this, too:

EFFECTS:

Ketamine can produce hallucinations, impaired judgment and perception, paranoia and dissociate state in which the user feels as if the mind is "separated" from their body.

Can produce a comatose state for the user and in certain situations death.

Blocks feelings of pain.

Can cause respiratory depression, but not of central nervous system.

Effects can be similar to PCP (that's the angel dust if I remember correctly) including numbness, loss of coordination, sense of invulnerability, muscle rigidity, aggressive/violent behavior, slurred or blocked speech, exaggerated sense of strength, and blank stares.

Large doses can produce vomiting, convulsions and may lead to oxygen starvation to the brain and muscles.

Effects generally last an hour, but can last up to 4-6 hours. Generally, it takes 24-48 hours before the user feels "normal" again. (hm!)

In addition it is also used as a date-rape drug. (how awful!) it is commonly used on children having dental work done. lovely. now the good news:

Sevoflurane comes to SCVEC

In order to offer our critical patients the safest anesthetic protocol possible, SCVEC is adding in a Sevoflo vaporizer. This latest generation gas anesthetic has a much wider margin of safety than even the very safe Isoflourane we are currently using. We will be able to choose between which anesthetic we want for each patient-- giving us the ability to reserve the very expensive but safer Sevoflo for the critical patients that need it the most.

--------

Q. I would appreciate if someone can give me some details on why the anesthesia Ketamine sometimes causes severe reactions and even death in some kittens/cats? Does it cause problems in mixed breeds or is it that Bengals and perhaps other purebreds are more sensitive to it? Any info on this matter would be greatly appreciated and forwarded to a customer. 

Here's the combination used for the neuter on the 5 month old male which caused the severe reaction: They used Zylazine (2 mg.) as a sedative; then Ketamine to put him under; then Isoflourane as maintenance. Please advise me as to why this combination is dangerous and what combination is the safest? Thanks, 

-------

A1.  avoid - ketamine.  prefer - isoflourane

-------

A2.My vet has used Ketamine for over 300 spay/neuters for me not to mention shelter cats she does.  She has never lost one of mine or the shelter cats using this.  It should not be used alone but it is very safe when used properly.  I just had 7 kittens done at 10 and 11 weeks today and all were up and around by the time I came to the computer room.

---------

A3. You are correct.  Generally, ketamine is safe but, if a cat is going to have a reaction typically it will be to ketamine thus making Isoflourane the anesthsia of choice - even the majority of Veterinary references re ESN advise the use of Iso.

-------

A4. Here's a good site to read : http://www.cpb.uokhsc.edu/ojvr/0700.htm

A5. And another : http://www.wakeywakey.com/drugs/ketamine/effects.htm

A6. That was an interesting site. At last I have a few facts straightened out in my head about this drug (I hope).

In Australia we use a combination of one-third of a ml of (various brand names of) xylazine and one-third of a ml of ketamine. Vets assure me here that there is rarely a problem with it and most say they have never even heard of a problem with it.  It is used routinely in the bush (country areas) for animals.

However, my expensive vet says they don't use it because of the blood pressure problems that ketamine has, so they use 10 mls of alphaxaline (sp?) instead.  They suggest a blood test first to get a general anaesthetic profile and to see if all the organs are OK if you have any worries about
Ketamine. 

Strange isn't it, how two countries can be so different in the results. Perhaps you mix it in different qualities over there (in America)?


Back to "Tips for Bengal Cat Owners"

Last Updated: 7 September 2001